An Attempt to Produce Mutations Through Hybridization

An attempt to produce hypersplenism in the dog, using methylcellulose.

By S. NI. \VEISSMAN, T. A. \\‘ALDMANN, E. LEvIN, AND N. I. BERLIN I HE ROLE of the spleen in the control of production and destruction of erythrocytes in “hypersplenic” disease states is not well understood. The lack of a satisfactory experimental model in a large animal has handicapped laboratory investigations of hyperspienism. Effors to produce the syndrome by ligation of the spbenic vein or...

Correspondence: An attempt to produce immune complexes in experimental syphilis.

Effects of Body-Color Mutations on Vitality: An Attempt to Establish Easy-to-Breed See-Through Medaka Strains by Outcrossing

"See-through" strains of medaka are unique tools for experiments: their skin is transparent, and their internal organs can be externally monitored throughout life. However, see-through fish are less vital than normally pigmented wild-type fish, which allows only skilled researchers to make the most of their advantages. Expecting that hybrid vigor (heterosis) would increase the vitality, we outc...

Studies in Glomerulonephritis. Iii. an Attempt to Produce Glomerulonephritis by Repeated Injections of Bacteria. by Harold

The present paper records an effort to reproduce glomerular nephritis in animals by inoculations of bacteria, especially by repeated inoculations such as might be expected to evoke phenomena of immuni ty , allergy, or sensitization. The indication for the a t t empt is found in the hypotheses pu t forth b y several writers in explanation of diffuse glomerulonephrifis, especially tha t occurring...

An attempt to produce a unilateral smoking dog using the contralateral lung as control.

Left mainstem bronchus as it is transected at carma. FIGURE 1B: Left main stem bronchus open at distal end plus tracheal end closed. Insert shows teflon tube being anastomosed to distal left bronchus. The carcinogenicity of tobacco tar for the skin of mice was proved by Wynder, Graham, and Croninger in 1953.' Rockey and co-workers found that tobacco tar applied directly to the bronchial mucosa ...